Gene information
Official symbol GSTM1
Official full name glutathione S-transferase mu 1
Gene type protein-coding gene
Chromosome1p13.3
Alias symbolMU; H-B
Previous symbolGST1
Gene familySoluble glutathione S-transferases
Resources
Entrez Gene 2944
HGNC HGNC:4632
Ensembl ENSG00000134184
Vega OTTHUMG00000011635
UCSC uc001dyk.4
GO terms: 32 records
GO Description Category LogP Number of genes Detail
GO:0001676 long-chain fatty acid metabolic process GO Biological Processes -13.6883394 17 More
GO:0004364 glutathione transferase activity GO Molecular Functions -3.62663932 4 More
GO:0006518 peptide metabolic process GO Biological Processes -2.74792434 15 More
GO:0006575 cellular modified amino acid metabolic process GO Biological Processes -7.43961662 26 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006633 fatty acid biosynthetic process GO Biological Processes -12.0711739 16 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006749 glutathione metabolic process GO Biological Processes -3.95134537 6 More
GO:0006790 sulfur compound metabolic process GO Biological Processes -3.12963557 12 More
GO:0006805 xenobiotic metabolic process GO Biological Processes -8.19045514 12 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO Molecular Functions -2.27622518 4 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033559 unsaturated fatty acid metabolic process GO Biological Processes -16.8056258 19 More
GO:0042277 peptide binding GO Molecular Functions -10.2245210 22 More
GO:0042759 long-chain fatty acid biosynthetic process GO Biological Processes -7.41220618 7 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043603 cellular amide metabolic process GO Biological Processes -1.84597279 17 More
GO:0044272 sulfur compound biosynthetic process GO Biological Processes -2.83849636 7 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0051121 hepoxilin metabolic process GO Biological Processes -3.88065666 3 More
GO:0051122 hepoxilin biosynthetic process GO Biological Processes -3.88065666 3 More
GO:0071466 cellular response to xenobiotic stimulus GO Biological Processes -9.33788411 28 More
GO:0072330 monocarboxylic acid biosynthetic process GO Biological Processes -12.0346130 18 More
GO:0097237 cellular response to toxic substance GO Biological Processes -13.7473733 28 More
GO:0098754 detoxification GO Biological Processes -12.4136065 17 More
GO:1990748 cellular detoxification GO Biological Processes -12.8821364 16 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa00480 Glutathione metabolism KEGG Pathway -3.20525659 5 More
hsa00980 Metabolism of xenobiotics by cytochrome P450 KEGG Pathway -5.38623088 8 More
hsa00982 Drug metabolism - cytochrome P450 KEGG Pathway -7.86918833 10 More
hsa00983 Drug metabolism - other enzymes KEGG Pathway -2.57730801 5 More
hsa01524 Platinum drug resistance KEGG Pathway -2.75238159 5 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05204 Chemical carcinogenesis - DNA adducts KEGG Pathway -6.89688307 9 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
hsa05208 Chemical carcinogenesis - reactive oxygen species KEGG Pathway -3.44838603 10 More
hsa05225 Hepatocellular carcinoma KEGG Pathway -5.07719186 21 More
Drug-Gene interaction
view
Related drugs: 21 records
Drug name Interaction type Source PMID View
azathioprine PharmGKB 23787247 view
bleomycin PharmGKB 23323945 view
busulfan PharmGKB 23677058 view
chlorambucil NCI 15044619 view
clozapine PharmGKB 27168101 view
curcumin NCI 15044619 view
cyclophosphamide PharmGKB 27785604 view
dacarbazine PharmGKB 23323945 view
dicumarol NCI 15044619 view
docetaxel NCI 16765145 view
doxorubicin PharmGKB 23323945 view
irinotecan hydrochloride NCI 16865249 view
methotrexate NCI 17180579 view
nitroglycerin NCI 2110160 view
paclitaxel PharmGKB 26803611 view
prednisone NCI 11186134 view
sulfamethoxazole PharmGKB 11191886 view
sulforaphane NCI 16332662 view
trimethoprim PharmGKB 11191886 view
troglitazone NCI 12732844 view
vinblastine PharmGKB 23323945 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
GSTM1 null genotype genomics myocardial infarction[diagnosis] myocardial infarction Cora T et al. Mol Biol Rep. 2013
GSTM1 null genotype genomics myocardial infarction[diagnosis] myocardial infarction Khanam J et al. Rep Biochem Mol Biol. 2020
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